The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection

Jing Qi; Yang Zhou; Jiao Hua; Liying Zhang; Jialin Bian; Beibei Liu; Zicen Zhao; Shuilin Jin

The scRNA-seq data of the testis, fallopian tube, ovary, and uterus from the reproductive system were collected for analysis. The ratios of the TMPRSS2-expressed cell and the ACE2-expressed cell in the epithelial cells of the fallopian tube are 26· 5% and 1· 4% respectively (Fig. 4, Table 5 ), and the ovarian somatic cells contain 1% TMPRSS2-expressed cells and 1% ACE2-expressed cells, so the fallopian tube is identified as a high-risk organ. The testis is also identified as a high-risk organ because of the high expression level of TMPRSS2 and ACE2 (Supplementary File: Figure S27 , Table 5 ). Low ratios of ACE2expressed cells in the ovary and uterus mean the ovary and uterus are low infection risk organs (Supplementary File: Figures S28-S29) .