Author: Zhang, Yonghong; Qin, Ling; Zhao, Yan; Zhang, Ping; Xu, Bin; Li, Kang; Liang, Lianchun; Zhang, Chi; Dai, Yanchao; Feng, Yingmei; Sun, Jianping; Hu, Zhongjie; Xiang, Haiping; Knight, Julian C; Dong, Tao; Jin, Ronghua
Title: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with disease severity in COVID-19 Cord-id: 387spphe Document date: 2020_4_29
ID: 387spphe
Snippet: A major unanswered question in the current global COVID-19 outbreak is why a small minority of infected individuals develop severe disease. Here we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at risk individuals.
Document: A major unanswered question in the current global COVID-19 outbreak is why a small minority of infected individuals develop severe disease. Here we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at risk individuals.
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