Author: Lei, Lei; Qian, Hongbo; Yang, Xiaofang; Zhang, Xingzhe; Zhang, Dan; Dai, Tongxin; Guo, Rui; Shi, Lin; Cheng, Yanbin; Zhang, Baojun; Zhou, Xiaobo; Hu, Jinsong; Guo, Yaling
Title: The phenotypic changes of γδ T cells in COVIDâ€19 patients Cord-id: 3hsn6svq Document date: 2020_8_30
ID: 3hsn6svq
Snippet: A novel pneumoniaâ€associated respiratory syndrome named coronavirus diseaseâ€2019 (COVIDâ€19), which was caused by SARSâ€CoVâ€2,broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARSâ€CoVâ€2 infections. The information regarding the immunological characteristics in COVIDâ€19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVIDâ€19 patients to analyze chang
Document: A novel pneumoniaâ€associated respiratory syndrome named coronavirus diseaseâ€2019 (COVIDâ€19), which was caused by SARSâ€CoVâ€2,broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARSâ€CoVâ€2 infections. The information regarding the immunological characteristics in COVIDâ€19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVIDâ€19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARSâ€CoVâ€2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARSâ€CoVâ€2 infection.
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