Primary cutaneous anaplastic large cell lymphoma with marked spontaneous regression of organ manifestation after SARS‐CoV‐2 vaccination

Gambichler, T.; Boms, S.; Hessam, S.; Tischoff, I.; Tannapfel, A.; Lüttringhaus, T.; Beckman, J.; Stranzenbach, R.

Primary cutaneous anaplastic large cell lymphoma (pcALCL) belongs to the primary cutaneous CD30+ T cell lymphoproliferative disorders.(1) Systemic involvement is relatively rare and rather confined to the regional lymph nodes.(1)We describe a patient with recurrent pcALCL and diffuse lung manifestation which spontaneously regressed after one SARS‐CoV‐2 vaccination. We report a 57‐year‐old male patient with a 10‐year history of biopsy‐proven (CD30+, CD3+, CD4+, ALK‐, clonal T cell receptor gamma chain rearrangement) pcALCL with frequent local relapses predominantly affecting his scalp and neck.