Author: Zhang, Yanhua; Liu, Xi; Lin, Yun; Lian, Baoping; Lan, Wenjun; Iovanna, Juan L; Liu, Xiaoxuan; Peng, Ling; Xia, Yi
Title: Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy. Cord-id: dn6zdx3t Document date: 2020_7_29
ID: dn6zdx3t
Snippet: Novel nucleoside derivatives were developed using the strategy of "terminal N,N-dimethylation" to impart tertiary amines to a 1,2,4-triazole nucleoside. The obtained lead compounds displayed significantly improved anticancer activity with dual mechanisms of cell death via apoptosis and autophagy, offering a fresh perspective to searching for new anticancer candidates.
Document: Novel nucleoside derivatives were developed using the strategy of "terminal N,N-dimethylation" to impart tertiary amines to a 1,2,4-triazole nucleoside. The obtained lead compounds displayed significantly improved anticancer activity with dual mechanisms of cell death via apoptosis and autophagy, offering a fresh perspective to searching for new anticancer candidates.
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