Author: Lin, Meng-Hsuan; Huang, Yi-Ping; Chang, Chi-Fon; Hsu, Chun-Hua
Title: NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Cord-id: 35bu98qc Document date: 2021_1_24
ID: 35bu98qc
Snippet: SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the (1)H, (13)C, and (15)N resonance assignments of the SARS-CoV-2 macro domain. This work provides the ground for further structural deciphering and biophysical investigation in protein function and anti
Document: SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the (1)H, (13)C, and (15)N resonance assignments of the SARS-CoV-2 macro domain. This work provides the ground for further structural deciphering and biophysical investigation in protein function and antiviral agent design. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s12104-020-09996-x) contains supplementary material, which is available to authorized users.
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