Author: Guo, Jian-Ping; Petric, Martin; Campbell, William; McGeer, Patrick L
Title: SARS corona virus peptides recognized by antibodies in the sera of convalescent cases Cord-id: 29ih5c9v Document date: 2004_7_1
ID: 29ih5c9v
Snippet: We synthesized on cellulose membranes 4942 ten-amino-acid peptides which included all of the sequences predicted for the severe acute respiratory syndrome (SARS) corona virus. We probed these membranes with four pairs of acute and convalescent sera from recovered SARS cases. We correlated positively reacting peptides with the in vitro SARS-CoV neutralizing activity of the samples. We found that convalescent sera with high neutralizing activity recognized exclusively only a limited number of pept
Document: We synthesized on cellulose membranes 4942 ten-amino-acid peptides which included all of the sequences predicted for the severe acute respiratory syndrome (SARS) corona virus. We probed these membranes with four pairs of acute and convalescent sera from recovered SARS cases. We correlated positively reacting peptides with the in vitro SARS-CoV neutralizing activity of the samples. We found that convalescent sera with high neutralizing activity recognized exclusively only a limited number of peptides on the membranes. This suggests that antibodies against the epitopes represented by these peptides could be responsible for much of the SARS-CoV neutralizing activity. The findings have implications for monitoring humoral responses to SARS-CoV as well as for developing a successful SARS vaccine.
Search related documents:
Co phrase search for related documents- acute respiratory syndrome and additional peptide: 1, 2
- acute respiratory syndrome and adjacent peptide: 1, 2, 3, 4, 5, 6, 7, 8
- acute respiratory syndrome and administer easy: 1
Co phrase search for related documents, hyperlinks ordered by date