Selected article for: "chromosomal location and genetic code"
Author: Xavier Hernandez-Alias; Martin Schaefer; Luis Serrano
Title: Translational adaptation of human viruses to the tissues they infect
  • Document date: 2020_4_7
    • ID: 0rk2dw4e_1
    Snippet: Given the degeneracy of the genetic code, multiple 3-letter combinations of nucleotides can code for the same amino acid. Such synonymous codons are nevertheless not uniformly distributed along the genomes and can significantly deviate between organisms 1 . Evolutionary forces that explain the existence of the so-called codon bias include (1) a mutation pressure for a certain GC base composition depending on the species and chromosomal location, .....
    Document: Given the degeneracy of the genetic code, multiple 3-letter combinations of nucleotides can code for the same amino acid. Such synonymous codons are nevertheless not uniformly distributed along the genomes and can significantly deviate between organisms 1 . Evolutionary forces that explain the existence of the so-called codon bias include (1) a mutation pressure for a certain GC base composition depending on the species and chromosomal location, and (2) the translational selection for codons corresponding to highly expressed tRNA isoacceptors [2] [3] [4] .

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