Selected article for: "cancer therapy and gene delivery"
Author: Chen, Chi-Yuan; Lin, Chin-Yu; Chen, Guan-Yu; Hu, Yu-Chen
Title: Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications
  • Cord-id: 5ldpz9m9
  • Document date: 2011_4_28
    • ID: 5ldpz9m9
    Snippet: Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity, low cytotoxicity and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has gained explosive popularity as a gene delivery vector for a wide variety of applications. This article extensively reviews the recent understandings of the molecular mechanisms perti
    Document: Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity, low cytotoxicity and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has gained explosive popularity as a gene delivery vector for a wide variety of applications. This article extensively reviews the recent understandings of the molecular mechanisms pertinent to baculovirus entry and cellular responses, and covers the latest advances in the vector improvements and applications, with special emphasis on antiviral therapy, cancer therapy, regenerative medicine and vaccine.

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