Author: Hannemann, Holger
Title: Viral replicons as valuable tools for drug discovery Cord-id: dgwi24ou Document date: 2020_4_6
ID: dgwi24ou
Snippet: RNA viruses can cause severe diseases such as dengue, Lassa, chikungunya and Ebola. Many of these viruses can only be propagated under high containment levels, necessitating the development of low containment surrogate systems such as subgenomic replicons and minigenome systems. Replicons are self-amplifying recombinant RNA molecules expressing proteins sufficient for their own replication but which do not produce infectious virions. Replicons can persist in cells and are passed on during cell d
Document: RNA viruses can cause severe diseases such as dengue, Lassa, chikungunya and Ebola. Many of these viruses can only be propagated under high containment levels, necessitating the development of low containment surrogate systems such as subgenomic replicons and minigenome systems. Replicons are self-amplifying recombinant RNA molecules expressing proteins sufficient for their own replication but which do not produce infectious virions. Replicons can persist in cells and are passed on during cell division, enabling quick, efficient and high-throughput testing of drug candidates that act on viral transcription, translation and replication. This review will explore the history and potential for drug discovery of hepatitis C virus, dengue virus, respiratory syncytial virus, Ebola virus and norovirus replicon and minigenome systems.
Search related documents:
Co phrase search for related documents- action mode and adaptive mutation: 1, 2
- action mode and liver cirrhosis: 1, 2, 3, 4
- acute low respiratory infection and low respiratory infection: 1, 2, 3, 4, 5, 6, 7, 8
- acute respiratory syndrome virus and liver cirrhosis: 1, 2, 3, 4
- adaptive mutation and liver cirrhosis: 1
- liver cirrhosis and low grade fever: 1
Co phrase search for related documents, hyperlinks ordered by date