Author: Jing Qi; Yang Zhou; Jiao Hua; Liying Zhang; Jialin Bian; Beibei Liu; Zicen Zhao; Shuilin Jin
Title: The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection Document date: 2020_4_18
ID: grvc7pnt_38
Snippet: Based on TMPRSS2 expression level, we grouped the susceptible organs into three risk levels. In table 8, it is shown that lung, large intestine (colon and rectum), fallopian tube, and nose (nasal airway epithelium) are the most susceptible organs with TMPRSS2-expressed ration over 20%, and the result indicates the SARS-CoV-2 mainly attacks the respiratory system, the digestive system, and the reproductive system. The kidney, Small intestine (duod.....
Document: Based on TMPRSS2 expression level, we grouped the susceptible organs into three risk levels. In table 8, it is shown that lung, large intestine (colon and rectum), fallopian tube, and nose (nasal airway epithelium) are the most susceptible organs with TMPRSS2-expressed ration over 20%, and the result indicates the SARS-CoV-2 mainly attacks the respiratory system, the digestive system, and the reproductive system. The kidney, Small intestine (duodenum and jejunum), and testis are susceptible organs with moderate risk. In addition, the esophagus, gall bladder, brain (substantia nigra and cortex), and heart are identified to be the potentially susceptible organs.
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