Selected article for: "host range and narrow host range"
Author: Anastassia K. Pogoutse; Trevor F. Moraes
Title: Transferrin binding protein B and Transferrin binding protein A 2 expand the transferrin recognition range of Histophilus somni
  • Document date: 2019_8_9
    • ID: 2chmny8w_11
    Snippet: We observed no binding of NmTbpB to ovine transferrin within the concentration range used in 212 the experiment ( Figure 4D ). Taken together, our results suggest that H. somni TbpB is more 213 promiscuous than HsTbpA, and may, along with HsTbpA2, contribute to iron uptake from ovine Many pathogens have host species-specific receptors that arise from a process of coevolution 218 with the host. The sites that bear signatures of this coevolution te.....
    Document: We observed no binding of NmTbpB to ovine transferrin within the concentration range used in 212 the experiment ( Figure 4D ). Taken together, our results suggest that H. somni TbpB is more 213 promiscuous than HsTbpA, and may, along with HsTbpA2, contribute to iron uptake from ovine Many pathogens have host species-specific receptors that arise from a process of coevolution 218 with the host. The sites that bear signatures of this coevolution tend to be functionally important, 219 and so identifying them can lend insight into how a given receptor functions. Furthermore, host-220 specific interactions restrict pathogens to infecting a single host species or a narrow range of host 221 species (31). This host specificity or host restriction can create a barrier to studying infection in 222 animal models. A better understanding of the underlying mechanism of specificity could lead to 223 the design of animal infection models that mimic the progress of disease more accurately(32). 224

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