Author: Anastassia K. Pogoutse; Trevor F. Moraes
Title: Transferrin binding protein B and Transferrin binding protein A 2 expand the transferrin recognition range of Histophilus somni Document date: 2019_8_9
ID: 2chmny8w_20
Snippet: Firstly, while H. somni appears to grow to similar levels on ovine and caprine transferrins, it 280 appears to bind ovine transferrin with a higher affinity than caprine transferrin. This higher 281 relative affinity for ovine transferrin compared to caprine was also observed in experiments 282 using only HsTbpA2 and only HsTbpB. One possible explanation for this discrepancy is that 283 growth-promoting synergistic interactions between Tbps were .....
Document: Firstly, while H. somni appears to grow to similar levels on ovine and caprine transferrins, it 280 appears to bind ovine transferrin with a higher affinity than caprine transferrin. This higher 281 relative affinity for ovine transferrin compared to caprine was also observed in experiments 282 using only HsTbpA2 and only HsTbpB. One possible explanation for this discrepancy is that 283 growth-promoting synergistic interactions between Tbps were not picked up in the binding 284 assays. Measuring the growth of tbpB and tbpA2 knockouts on various transferrin iron sources 285 would provide insight into whether and how these receptors work together. Secondly, binding of 286
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