Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity

Takako I. Jones; Guo-Liang Chew; Pamela Barraza-Flores; Spencer Schreier; Monique Ramirez; Ryan D. Wuebbles; Dean J. Burkin; Robert K. Bradley; Peter L. Jones

(computed with Wagenmakers's framework [62] ), as observed in all possible pair-wise comparisons of experimental replicates. GO terms that were enriched amongst genes that exhibited increased or decreased expression in DUX4-induced versus control samples were identified with the GOseq method [63] , with a false-discovery rate threshold of 0.01. GO superterms ( Immune: immune, chemokine, interferon, wound, virus, cytokine, cytokine-, leukocyte, interleukin, Toll-like, toll-like, bacteri, inflamma, defense, immunological, immunoglobulin receptor, MHC, immunoglobulin, viral Differentially-expressed genes from the comparison of 9 control and 9 FSHD1 muscle biopsies [24] were defined as genes that were consistently differentially expressed at a threshold of Bayes factor ≥10 (computed with Wagenmakers's framework [62] ) in more than 50 out of 81 possible pair-wise comparisons between control and FSHD1 muscles. The intersection of these genes with orthologous differentially-expressed mouse genes from DUX4-induced vs control experiments are summarized in Table S3 .