Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity

Takako I. Jones; Guo-Liang Chew; Pamela Barraza-Flores; Spencer Schreier; Monique Ramirez; Ryan D. Wuebbles; Dean J. Burkin; Robert K. Bradley; Peter L. Jones

However, regenerating myofibers re-express many developmental isoforms of muscle proteins, including eMyHC, which can be detected within 3 days of injury and whose expression can persist for up to 3 weeks [89] [90] [91] . Therefore, a time course study of eMyHC expression after . CC-BY-NC 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/471094 doi: bioRxiv preprint DUX4-fl induction was performed on TA muscles ( Figure 11 ). As expected, the ACTA1-MCM controls showed no detectable expression of eMyHC in response to TMX ( Figure 11A-C) .