Author: Sanchita Bhadra; Miguel A. Saldaña; Hannah Grace Han; Grant L. Hughes; Andrew D. Ellington
Title: Multiplex logic processing isothermal diagnostic assays for an evolving virus Document date: 2018_9_23
ID: n5liudlg_19
Snippet: Similar to LAMP-OSD and 4-Plex-LAMP-4GO assays, 4-Plex-LAMP-2GO assays could also detect all nine Asian and both African ZIKV strains tested while suppressing spurious signal from dengue viruses (serotypes 1-4) ( Figure 7A ). Examination of endpoint smartphone images of 4-Plex-LAMP-2GO assays revealed that as few as 189 copies of a representative Asian ZIKV genomic RNA (quantified using NS2b-specific TaqMan qRT-PCR) could be reliably identified u.....
Document: Similar to LAMP-OSD and 4-Plex-LAMP-4GO assays, 4-Plex-LAMP-2GO assays could also detect all nine Asian and both African ZIKV strains tested while suppressing spurious signal from dengue viruses (serotypes 1-4) ( Figure 7A ). Examination of endpoint smartphone images of 4-Plex-LAMP-2GO assays revealed that as few as 189 copies of a representative Asian ZIKV genomic RNA (quantified using NS2b-specific TaqMan qRT-PCR) could be reliably identified using simple yes/no visual readout of presence or absence of fluorescence (Figures 7B and Supplementary Figure 1) . Similarly, African ZIKV genomic RNA could also be detected using smartphone imaged 4-Plex-LAMP-2GO assays ( Figure 7B ).
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