Selected article for: "gene expression and ISG expression"
Author: MJ Morwitzer; A Corona; L Zinzula; E Fanunza; C Nigri; S Distinto; C Vornholt; V Kumar; E Tramontano; SP Reid
Title: Mutation of Ebola virus VP35 Ser129 uncouples interferon antagonist and replication functions
  • Document date: 2019_8_7
    • ID: cbyzdnrp_68
    Snippet: To assess a role of Ser129 in VP35 function, we examined IFN antagonist function, including 440 VP35 inhibition impact on the RIG-I-mediated signaling cascade and subsequent impairment of 441 the interferon stimulated-gene (ISG) expression. Using a luciferase reporter gene assay, we first 442 evaluated VP35-WT and VP35-S129A inhibition of dsRNA-induced RIG-I activation of the IFN-β 443.....
    Document: To assess a role of Ser129 in VP35 function, we examined IFN antagonist function, including 440 VP35 inhibition impact on the RIG-I-mediated signaling cascade and subsequent impairment of 441 the interferon stimulated-gene (ISG) expression. Using a luciferase reporter gene assay, we first 442 evaluated VP35-WT and VP35-S129A inhibition of dsRNA-induced RIG-I activation of the IFN-β 443

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