Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Document date: 2020_2_10
ID: 7n8p9okf_48_1
Snippet: RNA viruses in Vero cells was observed independently in the virology laboratories in Leuven and in Leiden. It is thus unlikely that the lack of activity in Vero cells is related to problems with the experimental set-up. In preliminary experiments, we replaced the P3 cinnamoyl group of 11r by the fluorophor coumaryl and found by fluorescence microscopy that much more inhibitor appeared to accumulate in Huh7 cells compared to Vero cells (D.L., R.H......
Document: RNA viruses in Vero cells was observed independently in the virology laboratories in Leuven and in Leiden. It is thus unlikely that the lack of activity in Vero cells is related to problems with the experimental set-up. In preliminary experiments, we replaced the P3 cinnamoyl group of 11r by the fluorophor coumaryl and found by fluorescence microscopy that much more inhibitor appeared to accumulate in Huh7 cells compared to Vero cells (D.L., R.H. & Irina Majoul, unpublished).
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