Author: Haun, Brien K.; Lai, Chih-Yun; Williams, Caitlin A.; Wong, Teri Ann; Lieberman, Michael M.; Pessaint, Laurent; Andersen-Elyard, Hanne; Lehrer, Axel T.
Title: CoVaccine HTâ„¢ adjuvant potentiates robust immune responses to recombinant SARS-CoV-2 Spike S1 immunisation Cord-id: 5zj6f9rh Document date: 2020_7_26
ID: 5zj6f9rh
Snippet: The current COVID-19 pandemic has claimed hundreds of thousands of lives and its causative agent, SARS-CoV-2, has infected millions, globally. The highly contagious nature of this respiratory virus has spurred massive global efforts to develop vaccines at record speeds. In addition to enhanced immunogen delivery, adjuvants may greatly impact protective efficacy of a SARS-CoV-2 vaccine. To investigate adjuvant suitability, we formulated protein subunit vaccines consisting of the recombinant S1 do
Document: The current COVID-19 pandemic has claimed hundreds of thousands of lives and its causative agent, SARS-CoV-2, has infected millions, globally. The highly contagious nature of this respiratory virus has spurred massive global efforts to develop vaccines at record speeds. In addition to enhanced immunogen delivery, adjuvants may greatly impact protective efficacy of a SARS-CoV-2 vaccine. To investigate adjuvant suitability, we formulated protein subunit vaccines consisting of the recombinant S1 domain of SARS-CoV-2 Spike protein alone or in combination with either CoVaccine HTâ„¢ or Alhydrogel. CoVaccine HTâ„¢ induced high titres of antigen-binding IgG after a single dose, facilitated affinity maturation and class switching to a greater extent than Alhydrogel and elicited potent cell-mediated immunity as well as virus neutralising antibody titres. Data presented here suggests that adjuvantation with CoVaccine HTâ„¢ can rapidly induce a comprehensive and protective immune response to SARS-CoV-2.
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