Author: Zhichao Feng; Jennifer Li; Shanhu Yao; Qizhi Yu; Wenming Zhou; Xiaowen Mao; Huiling Li; Wendi Kang; Xin Ouyang; Ji Mei; Qiuhua Zeng; Jincai Liu; Xiaoqian Ma; Pengfei Rong; Wei Wang
Title: The Use of Adjuvant Therapy in Preventing Progression to Severe Pneumonia in Patients with Coronavirus Disease 2019: A Multicenter Data Analysis Document date: 2020_4_10
ID: k65501xp_41
Snippet: ACE2, an important component of the renin-angiotensin-aldosterone system (RAAS), is highly expressed in both the lung and myocardium and converts angiotensin II (AII) into angiotensin 1-7, which can downregulate ACE and directly cause vasodilatation. [23] [24] [25] Downregulation of ACE2 level has also been shown in hypertensive animal models, although there has been limited success in translational confirmation in human studies. 26, 27 None the .....
Document: ACE2, an important component of the renin-angiotensin-aldosterone system (RAAS), is highly expressed in both the lung and myocardium and converts angiotensin II (AII) into angiotensin 1-7, which can downregulate ACE and directly cause vasodilatation. [23] [24] [25] Downregulation of ACE2 level has also been shown in hypertensive animal models, although there has been limited success in translational confirmation in human studies. 26, 27 None the less, this may be exacerbated by the further reduction in available ACE2 following coronavirus infection. Both SARS-CoV and . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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