Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infection

Serpeloni, Juliana M.; Alves de Lima Neto, Quirino; Carolina Lucio, Léia; Ramão, Anelisa; Carvalho de Oliveira, Jaqueline; Fiori Gradia, Daniela; Malheiros, Danielle; Ferrasa, Adriano; Marchi, Rafael; Figueiredo, David A.L.; Silva, Wilson A.; Msf.Ribeiro, Enilze; Cólus, Ilce M.S.; Cavalli, Luciane R.

In this review, we highlight the interaction of SARS-CoV-2 virus and host genomes, reporting the current studies on the sequence analysis of SARS-CoV-2 isolates and host genomes from diverse world populations. The main genetic variants that are present in both the virus and host genomes were particularly focused on the ACE2 and TMPRSS2 genes, and their impact on the patients' susceptibility to the virus infection and severity of the disease. Finally, the interaction of the virus and host non-coding RNAs is described in relation to their regulatory roles in target genes and/or signaling pathways critically associated with SARS-CoV-2 infection. Altogether, these studies provide a significant contribution to the knowledge of SARS-CoV-2 mechanisms of infection and COVID-19 pathogenesis. The described genetic variants and molecular factors involved in host/virus genome interactions have significantly contributed to defining patient risk groups, beyond those based on patient age and comorbidities, and they are promising candidates to be potentially targeted in treatment strategies for COVID-19 and other viral infectious diseases.