Author: Daniel Bean; Zeljko Kraljevic; Thomas Searle; Rebecca Bendayan; Andrew Pickles; Amos Folarin; Lukasz Roguski; Kawsar Noor; Anthony Shek; Kevin o'gallagher; Rosita Zakeri; Ajay Shah; James Teo; Richard JB Dobson
Title: Treatment with ACE-inhibitors is associated with less severe disease with SARS-Covid-19 infection in a multi-site UK acute Hospital Trust Document date: 2020_4_11
ID: 60wcvkbn_12
Snippet: Findings from unadjusted logistic regression models indicated that individuals on ACEi had lower likelihood of severe disease (OR 0·42 (CI 0·14-1·00), p=0·058). These associations were only partially attenuated when adjustments for gender and age were included (Model 1 in Table 2 ). Furthermore, these associations remained significant and were only partially attenuated when the model was additionally adjusted for hypertension (Model 2 in Tabl.....
Document: Findings from unadjusted logistic regression models indicated that individuals on ACEi had lower likelihood of severe disease (OR 0·42 (CI 0·14-1·00), p=0·058). These associations were only partially attenuated when adjustments for gender and age were included (Model 1 in Table 2 ). Furthermore, these associations remained significant and were only partially attenuated when the model was additionally adjusted for hypertension (Model 2 in Table 2 ) and further for other comorbidities diabetes and ischaemic heart disease or heart failure (Model 3 in Table 2 ). Odds ratios and p-values for all variables in each model are shown in Supplementary Table 1. Males were found to have a higher likelihood of severe disease in Model 3 (OR 2.00 (CI 1.00-4.00), p=0.037).
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