Age, frailty and comorbidity as prognostic factors for short-term outcomes in patients with COVID-19 in geriatric care

Hägg, Sara; Jylhävä, Juulia; Wang, Yunzhang; Xu, Hong; Metzner, Carina; Annetorp, Martin; Garcia-Ptacek, Sara; Khedri, Masih; Boström, Anne-Marie; Kadir, Ahmadul; Johansson, Anna; Kivipelto, Miia; Eriksdotter, Maria; Cederholm, Tommy; Religa, Dorota

Abstract Objectives To analyze whether frailty and comorbidities are associated with in-hospital mortality and discharge to home in older adults hospitalized for coronavirus disease 2019 (COVID-19). Design Single-center observational study. Setting and Participants: Patients admitted to geriatric care in a large hospital in Sweden, between March 1st – June 11th 2020; 250 were treated for COVID-19 and 717 for other diagnoses. Methods COVID-19 diagnosis was clinically confirmed by positive RT-PCR test or, if negative, by other methods. Patient data were extracted from electronic medical records, which included Clinical Frailty Scale (CFS), and were further used for assessments of the Hospital Frailty Risk Score (HFRS) and the Charlson Comorbidity Index (CCI). In-hospital mortality and home discharge were followed up for up to 25 and 28 days, respectively. Multivariate Cox regression models adjusted for age and sex were used. Results Among the COVID-19 patients, in-hospital mortality rate was 24% and home discharge rate was 44%. Higher age was associated with in-hospital mortality (hazard ratio [HR]=1.05 per each year, 95% confidence interval [CI]=1.01-1.08) and lower probability of home discharge (HR=0.97, 95% CI=0.95-0.99). CFS (>5) and CCI, but not HFRS, were predictive of in-hospital mortality (HR=1.93, 95% CI=1.02-3.65 and HR=1.27, 95% CI=1.02-1.58, respectively). Patients with CFS>5 had a lower probability of being discharged home (HR=0.38, 95% CI=0.25-0.58). CCI and HFRS were not associated with home discharge. In general, effects were more pronounced in men. Acute kidney injury was associated with in-hospital mortality and hypertension with discharge to home. Other comorbidities (diabetes, cardiovascular disease, lung diseases, chronic kidney disease and dementia) were not associated with either outcome. Conclusions and Implications Of all geriatric COVID-19 patients, three out of four survived during the study period. Our results indicate that in addition to age, the level of frailty is a useful predictor of short-term COVID-19 outcomes in geriatric patients.