Author: Minfeng Liao; Yang Liu; Jin Yuan; Yanling Wen; Gang Xu; Juanjuan Zhao; Lin Chen; Jinxiu Li; Xin Wang; Fuxiang Wang; Lei Liu; Shuye Zhang; Zheng Zhang
Title: The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing Document date: 2020_2_26
ID: 8l1vfsbc_25
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.02. 23.20026690 doi: medRxiv preprint intriguing. We assumed that it might be related to bystander activation induced by hyper inflammation, or a delayed response to the infection in severe COVID-19. To further understand the relevant functional status of each NK and T cell subsets between mild and severe patients, we conducted GEX analysis. We .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.02. 23.20026690 doi: medRxiv preprint intriguing. We assumed that it might be related to bystander activation induced by hyper inflammation, or a delayed response to the infection in severe COVID-19. To further understand the relevant functional status of each NK and T cell subsets between mild and severe patients, we conducted GEX analysis. We found T cell activation, migration, calcium ion signaling molecules were upregulated in CD8 + T cells from mild cases, but the virus responses, metabolites and energy generation, and translation initiation molecules was upregulated in CD8 + T cells from severe cases ( Figure 3E and 3F). Thus, these data confirm our assumption that more effective CD8 + T cells in mild patients help to clear the viruses, while CD8 + T cells in severe patients are in preparation to proliferate.
Search related documents:
Co phrase search for related documents- bystander activation and severe infection: 1, 2
- bystander activation and virus clear: 1, 2
- bystander activation and virus response: 1
- calcium ion and cell activation: 1, 2, 3, 4
- calcium ion and severe case: 1
- calcium ion and severe infection: 1, 2
- calcium ion and severe patient: 1
- cell activation and hyper inflammation: 1, 2
- cell activation and mild patient: 1
- cell activation and severe case: 1, 2, 3
- cell activation and severe infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65
- cell activation and severe patient: 1, 2, 3, 4, 5
- cell activation and signaling molecule: 1, 2, 3, 4, 5, 6, 7
- cell activation and translation initiation: 1, 2, 3
- cell activation and virus clear: 1, 2
- cell activation and virus response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45
- cell subset and hyper inflammation: 1
- cell subset and severe infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cell subset and signaling molecule: 1, 2
Co phrase search for related documents, hyperlinks ordered by date