Selected article for: "cell migration and NK cell"

Author: Minfeng Liao; Yang Liu; Jin Yuan; Yanling Wen; Gang Xu; Juanjuan Zhao; Lin Chen; Jinxiu Li; Xin Wang; Fuxiang Wang; Lei Liu; Shuye Zhang; Zheng Zhang
Title: The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing
  • Document date: 2020_2_26
  • ID: 8l1vfsbc_25
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.02. 23.20026690 doi: medRxiv preprint intriguing. We assumed that it might be related to bystander activation induced by hyper inflammation, or a delayed response to the infection in severe COVID-19. To further understand the relevant functional status of each NK and T cell subsets between mild and severe patients, we conducted GEX analysis. We .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.02. 23.20026690 doi: medRxiv preprint intriguing. We assumed that it might be related to bystander activation induced by hyper inflammation, or a delayed response to the infection in severe COVID-19. To further understand the relevant functional status of each NK and T cell subsets between mild and severe patients, we conducted GEX analysis. We found T cell activation, migration, calcium ion signaling molecules were upregulated in CD8 + T cells from mild cases, but the virus responses, metabolites and energy generation, and translation initiation molecules was upregulated in CD8 + T cells from severe cases ( Figure 3E and 3F). Thus, these data confirm our assumption that more effective CD8 + T cells in mild patients help to clear the viruses, while CD8 + T cells in severe patients are in preparation to proliferate.

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