Author: Shay Leary; Silvana Gaudieri; Abha Chopra; Suman Pakala; Eric Alves; Mina John; Suman Das; Simon Mallal; Phillips Jane Phillips
Title: Three adjacent nucleotide changes spanning two residues in SARS-CoV-2 nucleoprotein: possible homologous recombination from the transcription-regulating sequence Document date: 2020_4_11
ID: 9xueqdri_10
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.10.029454 doi: bioRxiv preprint revert to wild type when the selective pressure is removed as the virus cannot negotiate the fitness valley to return to its previous optimal state 7 . We therefore predict that the K203/R204 (AAA CGA) change is likely to remain fixed and intermediates to the wild type are unlikely to be found. It will be c.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.10.029454 doi: bioRxiv preprint revert to wild type when the selective pressure is removed as the virus cannot negotiate the fitness valley to return to its previous optimal state 7 . We therefore predict that the K203/R204 (AAA CGA) change is likely to remain fixed and intermediates to the wild type are unlikely to be found. It will be critical to determine if the introduction of the AAACGA motif results in a replicative or other fitness cost to the virus, creates an alternative subgenomic mRNA transcript or RNA secondary structure or increases nucleocapsid activity as this could indicate that there may be viral attenuation as passage occurs globally through populations of diverse immunogenetic background.
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