Selected article for: "International license and RNA synthesis"
Author: Hazel Stewart; Katherine Brown; Adam M. Dinan; Nerea Irigoyen; Eric J. Snijder; Andrew E. Firth
Title: The transcriptional and translational landscape of equine torovirus
  • Document date: 2018_4_7
    • ID: mozfm5ds_37
    Snippet: to the hairpin ( Figure S6I ). Our results lend support to the hypothesis suggested 370 previously that a short conserved RNA hairpin, 174 nt upstream of the AUG start 371 . CC-BY 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/296996 doi: bioRxiv preprint codon of the EToV S protein gene, mediates discontinuous extension of.....
    Document: to the hairpin ( Figure S6I ). Our results lend support to the hypothesis suggested 370 previously that a short conserved RNA hairpin, 174 nt upstream of the AUG start 371 . CC-BY 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/296996 doi: bioRxiv preprint codon of the EToV S protein gene, mediates discontinuous extension of negative 372 strand RNA synthesis to produce this sgRNA (12) (Supplementary Figure 6) . The 373 predicted hairpin structure was not present in S gene chimaeric reads, indicating that 374 translocation may indeed be prompted by the RdRp encountering a physical block 375 after synthesising the reverse complement of the S ORF. This is in contrast to the 376 coronaviral and arteriviral mechanism, wherein RNA structures are insufficient and 377 an accompanying body TRS is required to act as a transcriptional attenuation signal, 378

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