Selected article for: "discontinuous RNA synthesis and trs sequence"
Author: Hazel Stewart; Katherine Brown; Adam M. Dinan; Nerea Irigoyen; Eric J. Snijder; Andrew E. Firth
Title: The transcriptional and translational landscape of equine torovirus
  • Document date: 2018_4_7
    • ID: mozfm5ds_40
    Snippet: The leader-TRS chimaeric reads mapping to the N protein gene initially appear 383 consistent with the coronaviral and arteriviral mechanism of TRS-driven 384 discontinuous RNA synthesis. However close inspection indicated that the 385 homologous motif mediating copy-choice recombination-like translocation and re-386 pairing of RNA strands was actually a short AGAA sequence, not the true TRS 387 (tetranucleotides underlined in Figures S6A and S6G .....
    Document: The leader-TRS chimaeric reads mapping to the N protein gene initially appear 383 consistent with the coronaviral and arteriviral mechanism of TRS-driven 384 discontinuous RNA synthesis. However close inspection indicated that the 385 homologous motif mediating copy-choice recombination-like translocation and re-386 pairing of RNA strands was actually a short AGAA sequence, not the true TRS 387 (tetranucleotides underlined in Figures S6A and S6G ). This would result in the 388 nascent anti-TRS mispairing with the leader TRS; two nucleotides are "skipped" once 389 reinitiation occurs. This may explain why the discontinuous mechanism is utilised so 390 rarely for this mRNA. 391

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