Selected article for: "evidence provide and low dose"
Author: Feyaerts, Adam F.; Luyten, Walter
Title: Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?
  • Cord-id: 2vn51ti3
  • Document date: 2020_7_25
    • ID: 2vn51ti3
    Snippet: SARS‐CoV‐2 causes the potentially fatal COVID-19 disease. Already during the outbreak of SARS‐CoV‐1, the use of vitamin C was suggested. Many patients with severe COVID-19 have elevated levels of the mediators interleukin-6 and endothelin-1. These mediators may explain the age-dependence of COVID-19 pneumonia, the preponderance of male and obese or hypertensive patients, as well as of persons of colour, and smokers. There is clear evidence that vitamin C in high doses can reduce these me
    Document: SARS‐CoV‐2 causes the potentially fatal COVID-19 disease. Already during the outbreak of SARS‐CoV‐1, the use of vitamin C was suggested. Many patients with severe COVID-19 have elevated levels of the mediators interleukin-6 and endothelin-1. These mediators may explain the age-dependence of COVID-19 pneumonia, the preponderance of male and obese or hypertensive patients, as well as of persons of colour, and smokers. There is clear evidence that vitamin C in high doses can reduce these mediators. Vitamin C is cheap and safe. Hence using a relatively low dose of vitamin C as prophylaxis, and in case of severe COVID-19 disease, an (intravenous) high-dose regimen may be beneficial. Ongoing clinical trials are expected to provide more definitive evidence

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