Author: Huang, Fengming; Guo, Jing; Zou, Zhen; Liu, Jun; Cao, Bin; Zhang, Shuyang; Li, Hui; Wang, Wei; Sheng, Miaomiao; Liu, Song; Pan, Jingcao; Bao, Changjun; Zeng, Mei; Xiao, Haixia; Qian, Guirong; Hu, Xinjun; Chen, Yuanting; Chen, Yu; Zhao, Yan; Liu, Qiang; Zhou, Huandi; Zhu, Jindong; Gao, Hainv; Yang, Shigui; Liu, Xiaoli; Zheng, Shufa; Yang, Jiezuan; Diao, Hongyan; Cao, Hongcui; Wu, Ying; Zhao, Min; Tan, Shuguang; Guo, Dan; Zhao, Xiliang; Ye, Yicong; Wu, Wei; Xu, Yingchun; Penninger, Josef M.; Li, Dangsheng; Gao, George F.; Jiang, Chengyu; Li, Lanjuan
Title: Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients Cord-id: 2vo80sry Document date: 2014_5_6
ID: 2vo80sry
Snippet: A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had been reported, highlighting the urgency of identifying biomarkers for predicting disease severity and fatal outcomes. Here, we show that plasma levels of angiotensin II, a major regulatory peptide of the renin–angiotensin system, are markedly
Document: A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had been reported, highlighting the urgency of identifying biomarkers for predicting disease severity and fatal outcomes. Here, we show that plasma levels of angiotensin II, a major regulatory peptide of the renin–angiotensin system, are markedly elevated in H7N9 patients and are associated with disease progression. Moreover, the sustained high levels of angiotensin II in these patients are strongly correlated with mortality. The predictive value of angiotensin II is higher than that of C-reactive protein and some clinical parameters such as the PaO(2)/FiO(2) ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen). Our findings indicate that angiotensin II is a biomarker for lethality in flu infections. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/ncomms4595) contains supplementary material, which is available to authorized users.
Search related documents:
Co phrase search for related documents- ace angiotensin ii and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- ace angiotensin ii and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67
- ace angiotensin ii and logistic regression: 1, 2, 3, 4, 5, 6, 7
- ace angiotensin ii and logistic regression analysis: 1, 2, 3
- ace angiotensin ii and lung function: 1, 2, 3, 4, 5
- ace angiotensin ii and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
- ace inhibitor and acute ards respiratory distress syndrome: 1, 2, 3, 4
- ace inhibitor and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
- ace inhibitor and logistic regression: 1, 2, 3, 4, 5, 6, 7
- ace inhibitor and logistic regression analysis: 1
- ace inhibitor and long period: 1
- ace inhibitor and lung function: 1, 2
- ace inhibitor and lung injury: 1, 2, 3, 4
- acute ards respiratory distress syndrome and liver support: 1, 2, 3
- acute ards respiratory distress syndrome and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- acute ards respiratory distress syndrome and logistic regression analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- acute ards respiratory distress syndrome and logistic regression independent predictor analysis: 1
- acute ards respiratory distress syndrome and long period: 1, 2
- acute ards respiratory distress syndrome and lung function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67
Co phrase search for related documents, hyperlinks ordered by date