Selected article for: "cell type and disease progression"

Author: Brennan, Laura C.; O’Sullivan, Andrew; MacLoughlin, Ronan
Title: Cellular Therapy for the Treatment of Paediatric Respiratory Disease
  • Cord-id: 6fc7cnw1
  • Document date: 2021_8_18
  • ID: 6fc7cnw1
    Snippet: Respiratory disease is the leading cause of death in children under the age of 5 years old. Currently available treatments for paediatric respiratory diseases including bronchopulmonary dysplasia, asthma, cystic fibrosis and interstitial lung disease may ameliorate symptoms but do not offer a cure. Cellular therapy may offer a potential cure for these diseases, preventing disease progression into adulthood. Induced pluripotent stem cells, mesenchymal stromal cells and their secretome have shown
    Document: Respiratory disease is the leading cause of death in children under the age of 5 years old. Currently available treatments for paediatric respiratory diseases including bronchopulmonary dysplasia, asthma, cystic fibrosis and interstitial lung disease may ameliorate symptoms but do not offer a cure. Cellular therapy may offer a potential cure for these diseases, preventing disease progression into adulthood. Induced pluripotent stem cells, mesenchymal stromal cells and their secretome have shown great potential in preclinical models of lung disease, targeting the major pathological features of the disease. Current research and clinical trials are focused on the adult population. For cellular therapies to progress from preclinical studies to use in the clinic, optimal cell type dosage and delivery methods need to be established and confirmed. Direct delivery of these therapies to the lung as aerosols would allow for lower doses with a higher target efficiency whilst avoiding potential effect of systemic delivery. There is a clear need for research to progress into the clinic for the treatment of paediatric respiratory disease. Whilst research in the adult population forms a basis for the paediatric population, varying disease pathology and anatomical differences in paediatric patients means a paediatric-centric approach must be taken.

    Search related documents:
    Co phrase search for related documents
    • aberrant tissue and acute lung injury: 1
    • aberrant tissue and acute respiratory infection: 1
    • aberrant tissue repair and acute inflammation: 1
    • aberrant tissue repair and acute lung injury: 1
    • action potential mechanism and acute ards respiratory distress syndrome: 1, 2
    • action potential mechanism and acute lung injury: 1
    • acute ards respiratory distress syndrome and adaptive immune cell: 1, 2
    • acute inflammation and adaptive immune cell: 1, 2
    • acute lung injury and adaptive immune cell: 1