Author: Minfeng Liao; Yang Liu; Jin Yuan; Yanling Wen; Gang Xu; Juanjuan Zhao; Lin Chen; Jinxiu Li; Xin Wang; Fuxiang Wang; Lei Liu; Shuye Zhang; Zheng Zhang
Title: The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing Document date: 2020_2_26
ID: 8l1vfsbc_35
Snippet: Adaptive immune system is specific and memorizes the pathogens, including two arms, the antibody and T cell responses. Inducing adaptive immunity is also the aim of vaccination. SARS studies showed that binding and neutralizing antibodies are elicited in SARS-CoV infections, but their association with clinical outcomes is unclear [21] . Robust antibody responses were developed in severely infected SARS patients [22] . However, it is debated wheth.....
Document: Adaptive immune system is specific and memorizes the pathogens, including two arms, the antibody and T cell responses. Inducing adaptive immunity is also the aim of vaccination. SARS studies showed that binding and neutralizing antibodies are elicited in SARS-CoV infections, but their association with clinical outcomes is unclear [21] . Robust antibody responses were developed in severely infected SARS patients [22] . However, it is debated whether antibody-dependent enhancement played roles in disease exacerbation [23, 24] . Memory T cell responses are induced and maintained in SARS-CoV infected subjects [25] . T cell immunity was also confirmed to be necessary for resolving the viral infection in mouse models [26, 27] .
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