Selected article for: "lopinavir ritonavir and lotus china"
Author: Doggrell, Sheila A.
Title: Does lopinavir measure up in the treatment of COVID-19?
  • Cord-id: 32kwx4ol
  • Document date: 2020_6_12
    • ID: 32kwx4ol
    Snippet: INTRODUCTION: Lopinavir in combination with ritonavir is approved for the treatment of HIV and has recently been subject to a clinical trial in severe COVID-19. AREAS COVERED: This evaluation is of LOTUS China (the Lopinavir Trial for Suppression of SARS-Cov-2 in China), which was a randomized trial in hospitalized subjects with COVID-9 in a respiratory sample and pneumonia. As, in severe COVID-19, lopinavir/ritonavir had no beneficial effects but increased gastrointestinal adverse effects, this
    Document: INTRODUCTION: Lopinavir in combination with ritonavir is approved for the treatment of HIV and has recently been subject to a clinical trial in severe COVID-19. AREAS COVERED: This evaluation is of LOTUS China (the Lopinavir Trial for Suppression of SARS-Cov-2 in China), which was a randomized trial in hospitalized subjects with COVID-9 in a respiratory sample and pneumonia. As, in severe COVID-19, lopinavir/ritonavir had no beneficial effects but increased gastrointestinal adverse effects, this combination should not be used at this stage of COVID-19. EXPERT OPINION: In my opinion, the rationale for undertaking a trial of lopinavir/ritonavir in COVID-19 was poor. The analysis of a modified intention to treat group analysis in LOTUS China may have introduced bias. After LOTUS China, there is probably no future for lopinavir in the treatment of severe COVID-19, but some clinical trials for prevention or in various stages of COVID-19 have recently started or are ongoing. The major limitation of these trials is that as lopinavir does not inhibit COVID-19, it is unlikely to prevent infection, reduce viral load, or reduce the severity. However, these trials may be worthwhile in finally determining whether lopinavir has any role in preventing or treating COVID-19.

    Search related documents:
    Co phrase search for related documents
    • acute illness and lopinavir ritonavir: 1, 2, 3, 4, 5, 6
    • acute respiratory syndrome and local standard: 1, 2, 3, 4, 5, 6
    • acute respiratory syndrome and lopinavir clinical trial: 1, 2
    • acute respiratory syndrome and lopinavir drug ritonavir: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • acute respiratory syndrome and lopinavir drug ritonavir compare: 1
    • acute respiratory syndrome and lopinavir ritonavir: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory syndrome and lopinavir ritonavir combination: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory syndrome and lopinavir ritonavir common: 1
    • acute respiratory syndrome and lopinavir ritonavir compare: 1
    • acute respiratory syndrome and lopinavir ritonavir group: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • acute respiratory syndrome and lopinavir ritonavir therapeutic effect: 1
    • acute respiratory syndrome and lopinavir sars cov inhibit: 1, 2
    • acute respiratory syndrome and lopinavir sars inhibit: 1, 2
    • acute respiratory syndrome and lopinavir sars vitro effective: 1
    • acute respiratory syndrome and lopinavir show: 1, 2, 3
    • acute respiratory syndrome and lopinavir therapeutic effect: 1
    • local standard and lopinavir ritonavir: 1, 2
    • local standard and lopinavir ritonavir combination: 1