Selected article for: "viral replication and vivo replication"
Author: Antonio Gonçalves; Julie Bertrand; Ruian Ke; Emmanuelle Comets; Xavier de Lamballerie; Denis Malvy; Andrés Pizzorno; Olivier Terrier; Manuel Rosa Calatrava; France Mentré; Patrick Smith; Alan S Perelson; Jérémie Guedj
Title: Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load
  • Document date: 2020_4_7
    • ID: n6l2804j_3
    Snippet: Fitting mathematical models of viral dynamics to in vivo data can provide estimates of 67 parameters driving viral replication. Such models can then be used to predict the needed 68 efficacy of treatments and to optimize their use [2]. By combining these predictions with the 69 expected drug concentrations and EC 50 of drug candidates, one can anticipate the effects of 70 various dosing regimens (doses, timing of treatment initiation) on viral lo.....
    Document: Fitting mathematical models of viral dynamics to in vivo data can provide estimates of 67 parameters driving viral replication. Such models can then be used to predict the needed 68 efficacy of treatments and to optimize their use [2]. By combining these predictions with the 69 expected drug concentrations and EC 50 of drug candidates, one can anticipate the effects of 70 various dosing regimens (doses, timing of treatment initiation) on viral load dynamics. 71

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