Author: Syrimi, Eleni; Fennell, Eanna; Richter, Alex; Vrljicak, Pavle; Stark, Richard; Ott, Sascha; Murray, Paul G; Al-abadi, Eslam; Chikermane, Ashish; Dawson, Pamela; Hackett, Scott; Jyothish, Deepthi; Kanthimathinathan, Hari Krishnan; Monaghan, Sean; Nagakumar, Prasad; Scholefield, Barnaby R; Welch, Steven; Kearns, Pamela; Taylor, Graham
Title: Single-cell RNA-seq reveals profound monocyte changes in Paediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 infection (PIMS-TS) Cord-id: 6eivv0d9 Document date: 2020_8_7
ID: 6eivv0d9
Snippet: Paediatric inflammatory multisystem inflammatory syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) is a new disease with overlapping features of Kawasaki disease (KD) and toxic shock syndrome. Unbiased single cell RNA sequencing analysis of peripheral blood mononuclear cells from PIMS-TS and KD patients shows monocytes are the main source of pro-inflammatory cytokines and large changes in the frequency of classical, intermediate and non-classical monocytes occur in both diseases
Document: Paediatric inflammatory multisystem inflammatory syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) is a new disease with overlapping features of Kawasaki disease (KD) and toxic shock syndrome. Unbiased single cell RNA sequencing analysis of peripheral blood mononuclear cells from PIMS-TS and KD patients shows monocytes are the main source of pro-inflammatory cytokines and large changes in the frequency of classical, intermediate and non-classical monocytes occur in both diseases.
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