Author: Dorothea Bestle; Miriam Ruth Heindl; Hannah Limburg; Thuy Van Lam van; Oliver Pilgram; Hong Moulton; David A. Stein; Kornelia Hardes; Markus Eickmann; Olga Dolnik; Cornelius Rohde; Stephan Becker; Hans-Dieter Klenk; Wolfgang Garten; Torsten Steinmetzer; Eva Böttcher-Friebertshäuser
Title: TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets Document date: 2020_4_15
ID: anedg12x_6
Snippet: In December 2019, a new coronavirus (CoV) emerged which rapidly spreads around the 56 world causing a pandemic never observed before with these viruses. The virus was identified 57 as a new member of the lineage b of the genus Betacoronavirus that also contains the 2002 58 severe acute respiratory syndrome (SARS)-CoV and was named SARS-CoV-2 by the WHO. 59 surface glycoprotein hemagglutinin (HA) of human influenza A viruses (Böttcher et al., 200.....
Document: In December 2019, a new coronavirus (CoV) emerged which rapidly spreads around the 56 world causing a pandemic never observed before with these viruses. The virus was identified 57 as a new member of the lineage b of the genus Betacoronavirus that also contains the 2002 58 severe acute respiratory syndrome (SARS)-CoV and was named SARS-CoV-2 by the WHO. 59 surface glycoprotein hemagglutinin (HA) of human influenza A viruses (Böttcher et al., 2006) . Moreover, pretreatment of human Caco-2 colon and human airway cells with the broad range 125 inhibitor camostat mesylate that also inhibits TMPRSS2 activity, markedly reduced entry of 126 SARS-CoV-2 as well as VSV pseudotypes containing the SARS-CoV-2 S protein. This 127 indicates that a trypsin-like serine protease is crucial for SARS-CoV-2 entry into these cells. 128
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