Author: Dorothea Bestle; Miriam Ruth Heindl; Hannah Limburg; Thuy Van Lam van; Oliver Pilgram; Hong Moulton; David A. Stein; Kornelia Hardes; Markus Eickmann; Olga Dolnik; Cornelius Rohde; Stephan Becker; Hans-Dieter Klenk; Wolfgang Garten; Torsten Steinmetzer; Eva Böttcher-Friebertshäuser
Title: TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets Document date: 2020_4_15
ID: anedg12x_8
Snippet: In the present study we demonstrate that the S protein of SARS-CoV-2 is activated by 135 TMPRSS2 and furin. We also show that inhibitors against both proteases strongly suppress 136 virus replication in human airway epithelial cells and that the combination of both types of 137 inhibitors has a synergistic effect on virus reduction. Our results show that this approach has 138 a high therapeutic potential for treatment of COVID-19. Cleavage of SAR.....
Document: In the present study we demonstrate that the S protein of SARS-CoV-2 is activated by 135 TMPRSS2 and furin. We also show that inhibitors against both proteases strongly suppress 136 virus replication in human airway epithelial cells and that the combination of both types of 137 inhibitors has a synergistic effect on virus reduction. Our results show that this approach has 138 a high therapeutic potential for treatment of COVID-19. Cleavage of SARS-CoV-2 S1/S2 site FRET-substrates by furin 144
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