Author: Ryan M. Carey; Jenna R. Freund; Benjamin M. Hariri; Nithin D. Adappa; James N. Palmer; Robert J. Lee
Title: Altered polarization of PAR-2 signaling during airway epithelial remodeling Document date: 2020_1_9
ID: 8iet67u3_20
Snippet: In primary ALIs at 5 days after seeding, when ALIs have electrical resistance but cilia have not yet developed, both apical or basolateral 2FLI or trypsin induced calcium responses (Fig 3A and F) . After a saturating dose of apical 2FLI, another increase in apical 2FLI did not elicit a further response, while application of basolateral 2FLI did (Fig 3A, left) . This suggests that 2 separate pools of PAR-2 receptors exist, separated by the apica.....
Document: In primary ALIs at 5 days after seeding, when ALIs have electrical resistance but cilia have not yet developed, both apical or basolateral 2FLI or trypsin induced calcium responses (Fig 3A and F) . After a saturating dose of apical 2FLI, another increase in apical 2FLI did not elicit a further response, while application of basolateral 2FLI did (Fig 3A, left) . This suggests that 2 separate pools of PAR-2 receptors exist, separated by the apical-to-basolateral tight junction diffusional barrier. By day 21, responses to apical 2FLI or trypsin were lost, while responses to basolateral stimulation were intact (Fig 3B and F) .
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