Author: K. Reddisiva Prasanth; Minato Hirano; W. Samuel Fagg; Eileen T. McAnarney; Chao Shan; Xuping Xie; Adam Hage; Colette A. Pietzsch; Alexander Bukreyev; Ricardo Rajsbaum; Pei-Yong Shi; Mark T. Bedford; Shelton S. Bradrick; Vineet Menachery; Mariano A. Garcia-Blanco
Title: Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses Document date: 2020_3_27
ID: a0xfb9l4_9
Snippet: We tested a series of positive-sense single-stranded RNA viruses ((+) ss RNA viruses). A recombinant chikungunya virus (CHIKV), an alphavirus of the Togaviridae family was sensitive to TDRD3 knockout ( Fig 2B, left panel) , and coxsackievirus B3 (CVB3), an enterovirus of the family Picornaviridae, was dependent on TOP3B for efficient replication (Fig 2B, right panel) ......
Document: We tested a series of positive-sense single-stranded RNA viruses ((+) ss RNA viruses). A recombinant chikungunya virus (CHIKV), an alphavirus of the Togaviridae family was sensitive to TDRD3 knockout ( Fig 2B, left panel) , and coxsackievirus B3 (CVB3), an enterovirus of the family Picornaviridae, was dependent on TOP3B for efficient replication (Fig 2B, right panel) .
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