Selected article for: "control lung and healthy control lung"
Author: Pathak, Lekhika; Gayan, Sukanya; Pal, Bidisha; Talukdar, Joyeeta; Bhuyan, Seema; Sandhya, Sorra; Yeger, Herman; Baishya, Debabrat; Das, Bikul
Title: Coronavirus activates a stem cell-mediated defense mechanism that reactivates dormant tuberculosis: implications in COVID-19 pandemic
  • Cord-id: 691ybkan
  • Document date: 2020_6_8
    • ID: 691ybkan
    Snippet: We postulate that similar to bacteria, adult stem cells may also exhibit an innate defense mechanism to protect their niche. Here, we provide preliminary data on stem cell based innate defense against a mouse model of coronavirus, murine hepatitis virus-1 (MHV-1) infection. In a mouse model of mesenchymal stem cell (MSC) mediated Mycobacterium tuberculosis (Mtb) dormancy, MHV-1 infection in the lung exhibited 20 fold lower viral loads than the healthy control mice, suggesting the potential enhan
    Document: We postulate that similar to bacteria, adult stem cells may also exhibit an innate defense mechanism to protect their niche. Here, we provide preliminary data on stem cell based innate defense against a mouse model of coronavirus, murine hepatitis virus-1 (MHV-1) infection. In a mouse model of mesenchymal stem cell (MSC) mediated Mycobacterium tuberculosis (Mtb) dormancy, MHV-1 infection in the lung exhibited 20 fold lower viral loads than the healthy control mice, suggesting the potential enhancement of an anti-MHV-1 defense by Mtb. This defense mechanism involves the in vivo expansion and reprogramming of CD271+MSCs in the lung to an enhanced stemness phenotype. The reprogrammed MSCs facilitate the activation of stemness genes, intracellular Mtb replication, and extracellular release of Mtb. The conditioned media of the reprogrammed MSCs exhibit direct anti-viral activity in an in vitro model of MHV-1 induced toxicity to type II alveolar epithelial cells. Thus, our data suggest that reprogrammed MSCs exert a unique innate defense against MHV-1 by activating dormant Mtb. The molecular details of this anti-viral defense mechanism against coronavirus could be further studied to develop a vaccine against COVID-19.

    Search related documents:
    Co phrase search for related documents
    • acute ards respiratory distress syndrome and adaptive immune response innate: 1, 2, 3, 4, 5, 6, 7
    • acute ards respiratory distress syndrome and load study: 1
    • acute ards respiratory distress syndrome and lung alveolar: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute ards respiratory distress syndrome and lung alveolar epithelial cell: 1, 2, 3, 4, 5
    • acute ards respiratory distress syndrome and lung analyze: 1, 2, 3
    • acute ards respiratory distress syndrome and lung bone marrow: 1, 2
    • acute ards respiratory distress syndrome and lung compartment: 1
    • acute ards respiratory distress syndrome and lung decrease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • acute induce and adaptive immune response: 1
    • acute induce and adaptive immune response innate: 1
    • acute induce and lung alveolar: 1, 2
    • acute induce and lung decrease: 1
    • acute lung inflammation and adaptive immune response: 1
    • acute lung inflammation and lung alveolar: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • acute lung inflammation and lung analyze: 1
    • acute lung inflammation and lung compartment: 1
    • adaptive immune response and lung bone marrow: 1, 2
    • adaptive immune response and lung compartment: 1
    • adaptive immune response innate and lung bone marrow: 1