Selected article for: "high viral load and immune response"
Author: Meng, Lingzhang; Qin, Houji; Zhao, Jingjie; He, Siyuan; Wei, Qiuju; Wang, Zechen; Shen, Jiajia; Sooranna, Suren; Song, Jian
Title: Transcriptomic Signatures of Airway Epithelium Infected With SARS-CoV-2: A Balance Between Anti-infection and Virus Load
  • Cord-id: 6davmc77
  • Document date: 2021_8_23
    • ID: 6davmc77
    Snippet: COVID-19 pneumonia requires effective medical therapies. However, it is a challenge to find therapeutic drugs that not only inhibit viral replication, but also inhibit the accompanying cytokine storm and maintain an appropriate immune response. In this study, the effects of SARS-CoV-2 on gene expression in lung epithelial cells from patients with COVID-19 were systematically evaluated with bioinformatics analysis methods. Transcriptome expression specific to bystander (exposed but uninfected) an
    Document: COVID-19 pneumonia requires effective medical therapies. However, it is a challenge to find therapeutic drugs that not only inhibit viral replication, but also inhibit the accompanying cytokine storm and maintain an appropriate immune response. In this study, the effects of SARS-CoV-2 on gene expression in lung epithelial cells from patients with COVID-19 were systematically evaluated with bioinformatics analysis methods. Transcriptome expression specific to bystander (exposed but uninfected) and infected cells were found, and the vital pathways were identified by conducting differentially expressed gene analysis regarding the relationship between gene signatures of COVID-19 infection and disease severity. We found that a high viral load did not necessarily imply a low response of epithelial cells or a poor disease convalescence. The ability to distinguish the role of virus-correlated genes facilitates the development of potential new medicines and therapies for COVID-19 infection.

    Search related documents:
    Co phrase search for related documents
    • acute ards respiratory distress syndrome and load status: 1
    • acute ards respiratory distress syndrome and low high infection: 1
    • acute ards respiratory distress syndrome and low infection: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • acute ards respiratory distress syndrome and low infection high: 1
    • acute ards respiratory distress syndrome and low response: 1, 2, 3, 4
    • adaptive innate and adequate level: 1, 2
    • adaptive innate and load status: 1, 2
    • adaptive innate and low high infection: 1, 2
    • adaptive innate and low infection: 1, 2, 3, 4, 5, 6, 7, 8
    • adaptive innate and low infection high: 1, 2
    • adaptive innate and low response: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • load status and low infection: 1