Author: Feria Hikmet; Loren Méar; Mathias Uhlén; Cecilia Lindskog
Title: The protein expression profile of ACE2 in human tissues Document date: 2020_4_3
ID: 4fz6iqwy_3
Snippet: For a full understanding of the susceptibility for SARS-CoV-2 infection and the role of ACE2, it is necessary to study the cell type-specific expression of ACE2 in human tissues, both on the mRNA and protein level. The respiratory system is of special interest due to its high susceptibility to inhaled viruses, and most viruses infecting humans use different airway epithelial cells for replication. Expression of ACE2 in alveolar type II (AT2) cell.....
Document: For a full understanding of the susceptibility for SARS-CoV-2 infection and the role of ACE2, it is necessary to study the cell type-specific expression of ACE2 in human tissues, both on the mRNA and protein level. The respiratory system is of special interest due to its high susceptibility to inhaled viruses, and most viruses infecting humans use different airway epithelial cells for replication. Expression of ACE2 in alveolar type II (AT2) cells would therefore suggest that these cells can serve as a reservoir for viral invasion and facilitate SARS-CoV-2 replication in the lung. It is however also important to study other tissue locations that could serve as potential entry.
Search related documents:
Co phrase search for related documents- cell type and epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- cell type and high susceptibility: 1, 2, 3
- cell type and human infect: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cell type and human infect virus: 1, 2
- cell type and human tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
- cell type and lung SARS replication: 1, 2, 3, 4
- cell type and potential entry: 1, 2, 3, 4
- cell type and protein mrna: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30
- cell type and protein mrna level: 1, 2, 3, 4
- cell type and replication epithelial cell: 1, 2
- cell type and respiratory system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- cell type and SARS infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- cell type and SARS infection susceptibility: 1, 2, 3, 4, 5, 6, 7, 8
- cell type and SARS replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32
- cell type and tissue location: 1, 2
- cell type and viral invasion: 1, 2, 3
- cell type specific expression and epithelial cell: 1, 2, 3
- cell type specific expression and high susceptibility: 1
- cell type specific expression and human tissue: 1, 2, 3, 4, 5, 6
Co phrase search for related documents, hyperlinks ordered by date