Author: Lang, Peter; Eichholz, Thomas; Bakchoul, Tamam; Streiter, Monika; Petrasch, Maurice; Bösmüller, Hans; Klein, Reinhild; Rabsteyn, Armin; Lang, Anne-Marie; Adams, Constantin; Klingel, Karin; Gessner, Michaela; Rosenberger, Peter; Ruef, Peter; Handgretinger, Rupert
Title: Defibrotide for the treatment of PIMS-TS in two pediatric patients Cord-id: ay96ve5z Document date: 2020_9_19
ID: ay96ve5z
Snippet: The pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) is a severe complication of Covid-19. Since impaired coagulation, thrombosis/endotheliitis are suspected pathomechanisms, we treated two patients with defibrotide (DF), a pro-fibrinolytic, antithrombotic, anti-inflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized.
Document: The pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) is a severe complication of Covid-19. Since impaired coagulation, thrombosis/endotheliitis are suspected pathomechanisms, we treated two patients with defibrotide (DF), a pro-fibrinolytic, antithrombotic, anti-inflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized.
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