Selected article for: "antiviral target and host protease"
Author: Amrita Roy; Liangzhong Lim; Shagun Srivastava; Jianxing Song
Title: Unique properties of Zika NS2B-NS3pro complexes as decoded by experiments and MD simulations
  • Document date: 2016_9_28
    • ID: l82aakrk_4
    Snippet: Zika genome is translated into a single ~3,500-residue polyprotein, which is further cleaved into 3 structural proteins and 7 non-structural proteins (10) . The correct processing of the polyprotein is essential for replication of all flaviviruses, which requires both host proteases and a viral NS2B-NS3 protease (NS2B-NS3pro) (10, (12) (13) (14) (15) (16) (17) (18) . As a consequence, the flaviviral NS2B-NS3pro has been well-established to be a k.....
    Document: Zika genome is translated into a single ~3,500-residue polyprotein, which is further cleaved into 3 structural proteins and 7 non-structural proteins (10) . The correct processing of the polyprotein is essential for replication of all flaviviruses, which requires both host proteases and a viral NS2B-NS3 protease (NS2B-NS3pro) (10, (12) (13) (14) (15) (16) (17) (18) . As a consequence, the flaviviral NS2B-NS3pro has been well-established to be a key target for developing antiviral drugs (10, (12) (13) (14) (15) (16) (17) (18) (19) (20) (21) (22) . In the present study, we successfully obtained two enzymatically active Zika author/funder. All rights reserved. No reuse allowed without permission.

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