Author: Amrita Roy; Liangzhong Lim; Shagun Srivastava; Jianxing Song
Title: Unique properties of Zika NS2B-NS3pro complexes as decoded by experiments and MD simulations Document date: 2016_9_28
ID: l82aakrk_4
Snippet: Zika genome is translated into a single ~3,500-residue polyprotein, which is further cleaved into 3 structural proteins and 7 non-structural proteins (10) . The correct processing of the polyprotein is essential for replication of all flaviviruses, which requires both host proteases and a viral NS2B-NS3 protease (NS2B-NS3pro) (10, (12) (13) (14) (15) (16) (17) (18) . As a consequence, the flaviviral NS2B-NS3pro has been well-established to be a k.....
Document: Zika genome is translated into a single ~3,500-residue polyprotein, which is further cleaved into 3 structural proteins and 7 non-structural proteins (10) . The correct processing of the polyprotein is essential for replication of all flaviviruses, which requires both host proteases and a viral NS2B-NS3 protease (NS2B-NS3pro) (10, (12) (13) (14) (15) (16) (17) (18) . As a consequence, the flaviviral NS2B-NS3pro has been well-established to be a key target for developing antiviral drugs (10, (12) (13) (14) (15) (16) (17) (18) (19) (20) (21) (22) . In the present study, we successfully obtained two enzymatically active Zika author/funder. All rights reserved. No reuse allowed without permission.
Search related documents:
Co phrase search for related documents- antiviral drug and key target: 1, 2, 3, 4, 5, 6, 7
- antiviral drug and non structural protein: 1, 2, 3, 4, 5, 6, 7, 8, 9
- antiviral drug and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67
- antiviral drug and structural protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- correct processing and host protease: 1, 2
- correct processing and polyprotein correct processing: 1, 2, 3, 4
- correct processing and single polyprotein: 1, 2
- host protease and key target: 1, 2
- host protease and non structural protein: 1, 2, 3, 4
- host protease and polyprotein correct processing: 1, 2
- host protease and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- host protease and single polyprotein: 1, 2, 3, 4
- host protease and structural protein: 1, 2, 3, 4, 5, 6, 7, 8, 9
- key target and non structural protein: 1
- key target and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- key target and structural protein: 1, 2, 3, 4, 5, 6, 7, 8, 9
- non structural protein and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27
- non structural protein and single polyprotein: 1, 2, 3, 4
- non structural protein and structural protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85
Co phrase search for related documents, hyperlinks ordered by date