Author: Matthijs Kox; Tim Frenzel; Jeroen Schouten; Frank van de Veerdonk; Hans J.P.M. Koenen; Peter Pickkers
Title: No indications for overt innate immune suppression in critically ill COVID-19 patients Document date: 2020_4_6
ID: 3ngrtmb0_1
Snippet: Low monocytic (m)HLA-DR expression is the most widely used marker of innate immune suppression in critically ill patients. We recently showed that, in bacterial septic shock patients, low mHLA-DR expression is prevalent and associated with the development of secondary infections [1] . At the end of March 2020, there were in excess of 800.000 confirmed cases of coronavirus disease 2019 (COVID-19) worldwide, of whom more than 12.000 from the Nether.....
Document: Low monocytic (m)HLA-DR expression is the most widely used marker of innate immune suppression in critically ill patients. We recently showed that, in bacterial septic shock patients, low mHLA-DR expression is prevalent and associated with the development of secondary infections [1] . At the end of March 2020, there were in excess of 800.000 confirmed cases of coronavirus disease 2019 (COVID-19) worldwide, of whom more than 12.000 from the Netherlands. Several reports suggest that patients with severe COVID-19 may suffer from a hyperinflammatory "cytokine storm" [2, 3] . However, unlike SARS-CoV infection, high levels of anti-inflammatory mediators (e.g. IL-10 and IL-4) have also been reported in COVID-19 [3] .
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