Author: Matthijs Kox; Tim Frenzel; Jeroen Schouten; Frank van de Veerdonk; Hans J.P.M. Koenen; Peter Pickkers
Title: No indications for overt innate immune suppression in critically ill COVID-19 patients Document date: 2020_4_6
ID: 3ngrtmb0_7
Snippet: In conclusion, despite a pronounced inflammatory response in COVID-19 patients, our preliminary results indicate more moderate innate immune suppression compared with bacterial septic shock patients. These findings are in accordance with a low incidence of secondary infections in COVID-19 patients. Therefore, innate immune suppression as a negative feedback mechanism following pathogen-associated molecular pattern-induced inflammation appears les.....
Document: In conclusion, despite a pronounced inflammatory response in COVID-19 patients, our preliminary results indicate more moderate innate immune suppression compared with bacterial septic shock patients. These findings are in accordance with a low incidence of secondary infections in COVID-19 patients. Therefore, innate immune suppression as a negative feedback mechanism following pathogen-associated molecular pattern-induced inflammation appears less pronounced in COVID-19.
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