Author: Furuya, Y.; Müllbacher, A.
Title: Type I IFN Exhaustion is a Host Defence Protecting Against Secondary Bacterial Infections Cord-id: fzsc3n8m Document date: 2013_10_27
ID: fzsc3n8m
Snippet: Type I interferons (IFNâ€I) have been known for decades for their indispensable role in curtailing viral infections. It is, however, now also increasingly recognized that IFNâ€I is detrimental to the host in combating a number of bacterial infections. We have previously reported that viral infections induce partial lymphocyte activation, characterized by significant increases in the cell surface expression of CD69 and CD86, but not CD25. This systemic partial activation of lymphocytes, mediate
Document: Type I interferons (IFNâ€I) have been known for decades for their indispensable role in curtailing viral infections. It is, however, now also increasingly recognized that IFNâ€I is detrimental to the host in combating a number of bacterial infections. We have previously reported that viral infections induce partial lymphocyte activation, characterized by significant increases in the cell surface expression of CD69 and CD86, but not CD25. This systemic partial activation of lymphocytes, mediated by IFNâ€I, is rapid and is followed by a period of IFNâ€I unresponsiveness. Here we propose that IFNâ€I exhaustion that occurs soon after a primary viral infection may be a host response protecting it from secondary bacterial infections.
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