Selected article for: "muscle regeneration and severe moderate model"
Author: Takako I. Jones; Guo-Liang Chew; Pamela Barraza-Flores; Spencer Schreier; Monique Ramirez; Ryan D. Wuebbles; Dean J. Burkin; Robert K. Bradley; Peter L. Jones
Title: Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity
  • Document date: 2018_11_15
    • ID: 1yto01tr_54
    Snippet: In contrast, both the moderate model ( Figure 11E -J) and severe model ( Figure 11M -R) showed high levels of eMyHC, peaking at MD14 and SD9, respectively, thus confirming that the spike of DUX4-FL expression at these moderate and severe levels activates the skeletal muscle regeneration program. In contrast to eMyHC levels, expression of Mstn mRNA decreases in TA muscles as DUX4 levels and severity of pathology increased ( Figure S7 ). Together, .....
    Document: In contrast, both the moderate model ( Figure 11E -J) and severe model ( Figure 11M -R) showed high levels of eMyHC, peaking at MD14 and SD9, respectively, thus confirming that the spike of DUX4-FL expression at these moderate and severe levels activates the skeletal muscle regeneration program. In contrast to eMyHC levels, expression of Mstn mRNA decreases in TA muscles as DUX4 levels and severity of pathology increased ( Figure S7 ). Together, these results show increased DUX4 expression leads to the muscle remodeling and regeneration.

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