Author: Attri, Pankaj; Kurita, Hirofumi; Koga, Kazunori; Shiratani, Masaharu
Title: Impact of Reactive Oxygen and Nitrogen Species Produced by Plasma on Mdm2–p53 Complex Cord-id: 7zffekvp Document date: 2021_9_3
ID: 7zffekvp
Snippet: The study of protein–protein interactions is of great interest. Several early studies focused on the murine double minute 2 (Mdm2)–tumor suppressor protein p53 interactions. However, the effect of plasma treatment on Mdm2 and p53 is still absent from the literature. This study investigated the structural changes in Mdm2, p53, and the Mdm2–p53 complex before and after possible plasma oxidation through molecular dynamic (MD) simulations. MD calculation revealed that the oxidized Mdm2 bounded
Document: The study of protein–protein interactions is of great interest. Several early studies focused on the murine double minute 2 (Mdm2)–tumor suppressor protein p53 interactions. However, the effect of plasma treatment on Mdm2 and p53 is still absent from the literature. This study investigated the structural changes in Mdm2, p53, and the Mdm2–p53 complex before and after possible plasma oxidation through molecular dynamic (MD) simulations. MD calculation revealed that the oxidized Mdm2 bounded or unbounded showed high flexibility that might increase the availability of tumor suppressor protein p53 in plasma-treated cells. This study provides insight into Mdm2 and p53 for a better understanding of plasma oncology.
Search related documents:
Co phrase search for related documents- activity inhibit and low production: 1
- activity inhibit and lung cancer: 1, 2, 3, 4
- activity inhibit and lung cancer cell: 1
- liver cancer and lung cancer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42
- liver cancer and lung cancer cell: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date