Selected article for: "cc mouse and mouse population"
Author: Noll, Kelsey E.; Ferris, Martin T.; Heise, Mark T.
Title: The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions
  • Cord-id: 84sotgds
  • Document date: 2019_4_10
    • ID: 84sotgds
    Snippet: Host genetic variation has a major impact on infectious disease susceptibility. The study of pathogen resistance genes, largely aided by mouse models, has significantly advanced our understanding of infectious disease pathogenesis. The Collaborative Cross (CC), a newly developed multi-parental mouse genetic reference population, serves as a tractable model system to study how pathogens interact with genetically diverse populations. In this review, we summarize progress utilizing the CC as a plat
    Document: Host genetic variation has a major impact on infectious disease susceptibility. The study of pathogen resistance genes, largely aided by mouse models, has significantly advanced our understanding of infectious disease pathogenesis. The Collaborative Cross (CC), a newly developed multi-parental mouse genetic reference population, serves as a tractable model system to study how pathogens interact with genetically diverse populations. In this review, we summarize progress utilizing the CC as a platform to develop improved models of pathogen-induced disease and to map polymorphic host response loci associated with variation in susceptibility to pathogens.

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